FAK-ligand-2-C6-amine-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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FAKligand-2-C6-amine

Cat.No.:HY-179515

CASNo.:2414478-60-5

分⼦式:C₃₅H₄₇F₃N₆O₂

分⼦量:640.78

作⽤靶点:TargetProteinLigand-LinkerConjugates

作⽤通路:PROTAC

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性FAKligand-2-C6-amine是⼀种靶蛋⽩配体-连接⼦偶联物(targetproteinligandlinkerconjugate)，包含FAK

配体(HY-151010)和PROTAC连接⼦(HY-W011561)，可募集E3连接酶。FAKligand-2-C6-amine可⽤于合

成BSJ-04-146(HY-179512)[1]。

体外研究FAKPROTACscontaintwodifferentligandsconnectedbyalinker;oneisanE3ligaseligand(Thalidomide-

O-COOH)(HY-103597)andtheotherisforLigandsofFAKtargetprotein(FAKligand-2)(HY-151010).

PROTACsexploittheintracellularubiquitin-proteasomesystemtoselectivelydegradetargetproteins[1].

REFERENCES

[1].KoideE,etal.DevelopmentandCharacterizationofSelectiveFAKInhibitorsandPROTACswithInVivoActivity.Chembiochem.2023

Oct4;24(19):e202300141.

McePdfHeight

Caution:Producthasnotbe