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绝密★考试结束前
201510
00836
1()coincideemsp;
2()sphereemsp;
3()plantemsp;
4(选)WhenSteveColewasapostdoc,hehadanunusualhoy:
matchingartuyerswithartiststhattheymightlike.Thetaskmade
lookingatart,somethinghehadalwaysloved,evenmoreenjoyale.
“Therewasanextralayerofpupose.Ilovedtheailitytohelp
artistsIthoughtweregreattofindanappreciativeaudience,hesays.
Atthetime,itwasnothingmorethanaquirkysideline.Buthislatest
findingshavecausedCole-nowaprofessorattheCousinsCenter
forPsychoneuroimmunologyattheUniversityofCalifornia,Los
Angelestowonderwhethertheexhilarationandsenseofpurpose
thathefeltduringthatperiodmighthavedonemorethanhelphim
tofindhomesforunlovedpiecesofart.Itmighthaveenefitedhis
immunesystemtoo.Atonetime,mostself-respecting
moleculariologistswouldhavescoffedattheidea.Today,evidence
frommanystudiessuggeststhatmentalstatessuchasstresscan
influenceheath,Still,ithasproveddifficulttoexplainhowthis
happensatthemolecularlevelhowsujectivemoodsconnect
withthevastlycomplexphysiologyofthenervousandimmune
systems.Thefieldthatsearchesfortheseexplanations,knownas
psychoneuroimmunology(PNI),isoftencriticizedaslackingrigour.
Colesstatedaimistofixthat,andhistoolofchoiceisgenome-wide
transcriptionalanalysis;lookingatroadpattermsofgene
expressionincells.Myjoistoeahard-coretracker,he
says.“Howdothesementalstatesgetoutintotherestoftheody?
Withhiscolleagues,Colehaspulishedastringofstudies
suggestingthatnegativementalstatessuchasstressandloneliness
guideimmunetesponsesydrivingroadprogr
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