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IMU-856

Cat.No.:HY-177878

CASNo.:2303528-97-2

分⼦式:C₃₀H₃₈F₃N₇O₂

分⼦量:585.66

作⽤靶点:Sirtuin

作⽤通路:CellCycle/DNADamage;Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性IMU-856是⼀种⼝服有效的、全⾝作⽤的SIRT6⼩分⼦调节剂。IMU-856有效且选择性地抑制SIRT6去⼄酰化

酶活性，同时提⾼SIRT6蛋⽩⽔平。IMU-856可恢复肠道屏障功能，可⽤于研究乳糜泻。

IC50TargetSIRT6

REFERENCES

[1].DavesonAJM,etal.Safety,clinicalactivity,pharmacodynamics,andpharmacokineticsofIMU-856,aSIRT6modulator,incoeliac

disease:afirst-in-human,randomised,double-blind,placebo-controlled,phase1trial.LancetGastroenterolHepatol.2025Jan;10(1):44-54.

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