Indantadol-CHF-3381-free-base-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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Indantadol

Cat.No.:HY-101440

CASNo.:202844-10-8

Synonyms:CHF-3381freebase

分⼦式:C₁₁H₁₄N₂O

分⼦量:190.24

作⽤靶点:iGluR;MonoamineOxidase

作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Indantadol(CHF-3381freebase)是⼀种⼝服有效的、⾮选择性的NMDA拮抗剂和MAO抑制剂。Indantadol

以⾮竞争的⽅式阻断[³H]-MK-801与NMDA受体结合，IC50为8.1μM。Indantadol完全抑制了NMDA引起

的多巴胺释放。Indantadol可保护神经元，ED₅₀为35μM。Indantadol具有抗惊厥和抗⾼痛觉过敏活性。

IC50TargetNMDAReceptor

REFERENCES

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6.

[2].MattiaC,ColuzziF.Indantadol,anovelNMDAantagonistandnonselectiveMAOinhibitorforthepotentialtreatmentofneuropathic

pain.IDrugs.2007Sep;10(9):636-44.

[3].GandolfiO,etal.AnticonvulsantpreclinicalprofileofCHF3381:dopaminergicandglutamatergicmechanisms.PharmacolBiochem