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Inavolisib(Standard)

Cat.No.:HY-101562R

CASNo.:2060571-02-8

分⼦式:C₁₈H₁₉F₂N₅O₄

分⼦量:407.37

作⽤靶点:PI3K;ReferenceStandards;Apoptosis

作⽤通路:PI3K/Akt/mTOR;Others;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Inavolisib(Standard)是Inavolisib(HY-101562)的分析标准品。本产品⽤于研究及分析应⽤。Inavolisib

(GDC-0077)是⼀种有效的，具有⼝服活性的选择性PI3Kα抑制剂(IC50=0.038nM)。Inavolisib通过与PI3K

的ATP结合位点结合⽽发挥其活性，从⽽抑制了PIP2到PIP3的磷酸化。与野⽣型PI3Kα相⽐，Inavolisib对

突变体的选择性更⾼

IC50TargetIC50:0.038nM(PI3Kα)[1]

REFERENCES

[1].RHong,AbstractPD4-14:GDC-0077isaselectivePI3KalphainhibitorthatdemonstratesrobustefficacyinPIK3CAmutantbreast

cancermodelsasasingleagentandincombinationwithstandardofcaretherapies.2017SanAntonioBreastCancerSymposium.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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