rel-Talmapimod-hydrochloride-rel-SCIO-469-hydrochloride-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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rel-Talmapimodhydrochloride

Cat.No.:HY-10406B

CASNo.:879132-01-1

Synonyms:rel-SCIO-469hydrochloride

分⼦式:C₂₇H₃₁Cl₂FN₄O₃

分⼦量:549.46

作⽤靶点:p38MAPK;TNFReceptor;InterleukinRelated;VEGFR;

Apoptosis

作⽤通路:MAPK/ERKPathway;Apoptosis;Immunology/Inflammation;

ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性rel-Talmapimod(rel-SCIO-469)hydrochloride是⼀种⼝服有效的、选择性的p38αMAPK抑制剂，其IC50为

9nM。rel-Talmapimodhydrochloride通过抑制p38αMAPK通路，抑制炎症因⼦(如TNFα、IL-1β、IL-6

和VEGF)分泌，抑制⾎管⽣成和破⾻细胞活化。rel-Talmapimodhydrochloride抑制多发性⾻髓瘤细胞⽣长并

诱导凋亡(apoptosis)。rel-Talmapimodhydrochloride可⽤于研究多种⾎液恶性肿瘤(如多发性⾻髓瘤、⾻髓

增⽣异常综合征)。

IC50Targetp38αMAPKp38βMAPKIL-6IL-1β

9nM(IC50)90nM(IC50)

客户使⽤本产品发表的科研⽂献

•Cell.2020Aug6;182(3):685-712.e19.

•SciTranslMed.2018Jul18;10(450):eaaq1093.

•CellBiolToxicol.2021Aug;37(4):515-529.

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REFERENCES

1/2Mastero