rel-Avibactam-sodium-NXL-104-sodium-生命科学试剂-MCE.pdfVIP

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rel-Avibactamsodium

Cat.No.:HY-14879E

CASNo.:1383814-68-3

Synonyms:NXL-104sodium

分⼦式:C₇H₁₀N₃NaO₆S

分⼦量:287.23

作⽤靶点:Beta-lactamase;Bacterial

作⽤通路:Anti-infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性rel-Avibactam(NXL-104)sodium是⼀种β-内酰胺酶(β-lactamase)抑制剂，具有⼴谱抗菌活性。rel-

Avibactamsodium在与Ceftazidime(HY-B0593)的组合中，对产⽣AmblerA类和C类β-内酰胺酶的肠杆菌

科细菌表现出显著的抑制效果。rel-Avibactamsodium的IC50值远低于常⽤的β-内酰胺酶抑制剂Clavulanic

acid(HY-A0256)和Ticarcillin(HY-139805)，显⽰出其在抑制TEM-1和P99酶⽅⾯的⾼效性。

REFERENCES

[1].MeijiSeika,etal.Preparationofoptically-activediazabicyclooctanederivativeandmethodformanufacturingsame.WO2012086241.

[2].InvitroactivityofAVE1330A,aninnovativebroad-spectrumnon-beta-lactambeta-lactamaseinhibitor

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