Revamilast-GRC-4039-生命科学试剂-MCE.pdfVIP

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Revamilast

Cat.No.:HY-14869

CASNo.:893555-90-3

Synonyms:GRC4039

分⼦式:C₁₈H₉Cl₂F₂N₃O₄

分⼦量:440.18

作⽤靶点:Phosphodiesterase(PDE);TNFReceptor

作⽤通路:MetabolicEnzyme/Protease;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Revamilast(GRC4039)是⼀种⼝服有效的磷酸⼆酯酶-4(PDE4)抑制剂，IC50为3nM。Revamilast抑制TNF-

α产⽣。Revamilast可⽤于研究风湿性关节炎、斑块状⽜⽪藓、哮喘和其他炎症性疾病。

IC50TargetPDE4

3nM(IC50)

REFERENCES

[1].LiH,ZuoJ,TangW.Phosphodiesterase-4inhibitorsforthetreatmentofinflammatorydiseases.Frontiersinpharmacology.2018Oct

17;9:1048.

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