R-GNE-140-Standard-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

(R)-GNE-140(Standard)

Cat.No.:HY-100742AR

CASNo.:2003234-63-5

分⼦式:C₂₅H₂₃ClN₂O₃S₂

分⼦量:499.04

作⽤靶点:LactateDehydrogenase;ReferenceStandards

作⽤通路:MetabolicEnzyme/Protease;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(R)-GNE-140(Standard)是(R)-GNE-140(HY-100742A)的分析标准品。本产品⽤于研究及分析应⽤。(R)-GNE-

140是⼀种有效的LDHA抑制剂，对LDHA和LDHB的IC50值分别为3nM和5nM；(R)-GNE-140的活性是S

型异构体的18倍。

IC50TargetIC50:3nM(LDHA),5nM(LDHB)[1]

REFERENCES

[1].PurkeyHE,etal.CellActiveHydroxylactamInhibitorsofHumanLactateDehydrogenasewithOralBioavailabilityinMice.ACSMed

ChemLett.2016Aug26;7(10):896-901.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1Mast