RHPS4-Standard-生命科学试剂-MCE.pdfVIP

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RHPS4(Standard)

Cat.No.:HY-101089R

CASNo.:390362-78-4

分⼦式:C₂₃H₂₀F₂N₂O₄S

分⼦量:458.48

作⽤靶点:Telomerase;ReferenceStandards;Apoptosis

作⽤通路:CellCycle/DNADamage;Others;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性RHPS4(Standard)是RHPS4(HY-101089)的分析标准品。本产品⽤于研究及分析应⽤。RHPS4是有效的端粒

酶(telomerase)抑制剂(IC50=0.33μM)。RHPS4是DNA损伤的诱导剂。

IC50TargetIC50:0.33μM(telomeraseintheTRAPassay)[1].

REFERENCES

[1].JenniferCCookson,etal.PharmacodynamicsoftheG-quadruplex-stabilizingtelomeraseinhibitor3,11-difluoro-6,8,13-trimethyl-8H-

quino[4,3,2-kl]acridiniummethosulfate(RHPS4)invitro:activityinhumantumorcellscorrelateswithtelomerelengthandcanbeenhanced,

orantagonized,withcytotoxicagents.MolPharmacol.2005Dec;68(6):1551-8.

[2].EricaSalvati,etal.TelomeredamageinducedbytheG-quadruplexligandRHPS4hasanantitumoreffect.JClinInvest.2007

Nov;117(11):3236-47.

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