Rac-Sezolamide-hydrochloride-MK-927-生命科学试剂-MCE.pdfVIP

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(Rac)-Sezolamidehydrochloride

Cat.No.:HY-106331A

CASNo.:126453-94-9

Synonyms:MK-927;(Rac)-MK417

分⼦式:C₁₁H₁₉ClN₂O₄S₃

分⼦量:374.93

作⽤靶点:CarbonicAnhydrase

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(Rac)-Sezolamidehydrochloride(MK-927;(Rac)-MK417)是⼀种碳酸酐酶(carbonicanhydrase)抑制剂(CAI)

(Ki:12.0nM)。(Rac)-Sezolamidehydrochloride具有局部降低眼压(IOP)的作⽤。(Rac)-Sezolamide

hydrochloride可⽤于青光眼的研究[1]。

REFERENCES

[1].SugrueMF,etal.MK-927:atopicallyactiveocularhypotensivecarbonicanhydraseinhibitor.JOculPharmacol.1990Spring;6(1):9-22.

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