CDK6-ligand-Linker-Conjugate-1-生命科学试剂-MCE.pdfVIP

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CDK6ligand-LinkerConjugate1

Cat.No.:HY-180279

分⼦式:C₄₈H₆₆N₁₀O₅

分⼦量:863.1

作⽤靶点:TargetProteinLigand-LinkerConjugates;CDK

作⽤通路:PROTAC;CellCycle/DNADamage

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性CDK6ligand-LinkerConjugate1是⼀种靶蛋⽩配体-连接⼦偶联物(targetproteinligand-linkerconjugate)，

其包含CDK6配体(HY-180278)和连接⼦，可募集E3连接酶。CDK6ligand-LinkerConjugate1可⽤于合成

PROTACCDK6Degrader1(HY-180277)[1]。

IC50TargetCDK6

REFERENCES

[1].JeonE,etal.SelectiveCDK6DegradationviatheKLHDC2E3UbiquitinLigase.JMedChem.2025Dec11;68(23):25539-25568.

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