N-Octyl-α-4-epivalienamine-生命科学试剂-MCE.pdfVIP

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N-Octyl-α-4-epivalienamine

Cat.No.:HY-153922

CASNo.:942065-96-5

分⼦式:C₁₅H₂₉NO₄

分⼦量:287.4

作⽤靶点:Glycosidase

作⽤通路:MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性N-Octyl-α-4-epivalienamine是⼀种⼝服有效且能可穿透⾎脑屏障的分⼦伴侣，可诱导缺陷型β-半乳糖苷酶

(β-galactosidase)活性的⾼表达。N-Octyl-α-4-epivalienamine可改善GM1神经节苷脂沉积症⼩⿏模型的症

状并提⾼其存活率。N-Octyl-α-4-epivalienamine可⽤于神经遗传疾病的研究[1]。

IC50Targetβ-galactosidase

REFERENCES

[1].SuzukiY,etal.TherapeuticchaperoneeffectofN-octyl4-epi-β-valienamineonmurineG(M1)-gangliosidosis.MolGenetMetab.2012

May;106(1):92-8.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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