PX-478-Standard-生命科学试剂-MCE.pdfVIP

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PX-478(Standard)

Cat.No.:HY-10231R

CASNo.:685898-44-6

分⼦式:C₁₃H₂₀Cl₄N₂O₃

分⼦量:394.12

作⽤靶点:ReferenceStandards;HIF/HIFProlyl-Hydroxylase;Autophagy

作⽤通路:Others;MetabolicEnzyme/Protease;Autophagy

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PX-478(Standard)是PX-478(HY-10231)的分析标准品。本产品⽤于研究及分析应⽤。PX-478是⼀种具有⼝

服活性的HIF-1α抑制剂，并具有抗癌活性。PX-478可穿透⾎脑屏障。

IC50TargetHIF-1α[1]

REFERENCES

[1].PalayoorST,etal.PX-478,aninhibitorofhypoxia-induciblefactor-1alpha,enhancesradiosensitivityofprostatecarcinomacells.IntJ

Cancer.2008Nov15;123(10):2430-2437.

[2].AgarwalS,etal.InhibitionofHif1αpreventsbothtrauma-inducedandgeneticheterotopicossification.ProcNatlAcadSciUSA.2016

Jan19;113(3):E338-47.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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