药用高分子材料siRNA药物专家讲座.pptxVIP

姚老师作业：聚乳酸本体聚合工艺，对应机理和反应方程;第六章高分子纳米药品-siRNA药品;抗体:

Bindprotein,butonlyextracellularepitopes

Lowthroughput,highcost

反义RNA/核酶:

Stopgeneexpression(production),mostproteins

Chemicalstabilizationessential

Barriers:sequenceselection,potency,toxicities,…

RNA干扰:

Stopgeneexpression(production),mostproteins

Goodactivitywithoutchemicalstabilization

Rapidlyreplacingantisense:reallybetter?;RNA干扰（RNAinterference,RNAi）技术;RNAi

作用机制;Log[Oligo](M);;Target

ID;Company;难以被细胞摄取：大分子，阴离子;Nature,468,p487,Nov.25,;表示siRNA质粒DNA传递

病毒（NatureBiotechnology,,20:1006-10）