哈尔滨医科大学药理学1.pptVIP

药理学总论-绪言PharmacologyAVeryBasicIntro

Whatisadrug?anychemicalagentwhich affectsanybiologicalprocess

SourcesofDrugs

AnimalsPlantsMineralsSyntheticMicrobesGeneticengineeringdrugs

基因工程药物过程示意图①从细胞中分离出DNA①②③④⑤⑥②限制酶截取DNA片断③分离大肠杆菌中的质粒④DNA重组⑤用重组质粒转化大肠杆菌⑥培养大肠杆菌克隆大量基因

AgoalofGenomicsistofindandexpressgenesthatcodeforunknownpeptideswithsignificantbiologicalproperties,likereceptorsorenzymes.InareversePharmacologyapproachthispeptide,e.g.areceptor,isthenusedtofishforanaturalligand.Withreceptorandligandinhandthebiologicalroleofthere