血液系统药物.pptVIP

血液系统药物;Drugsaffectingthebloodandblood-formingorgans;heparin肝素

lowmolecularweightheparin低分子量肝素

dermatansulfate硫酸皮肤素

lepirudin重组水蛭素

coumarins香豆素类

warfarin华法林

dicoumarol双香豆素

acenocoumarol醋硝香豆素;Thrombosisinjuresvitalorgans;;StageI;Majorreactionsofbloodcoagulation;;Anticoagulantdrugs;1.Pharmacologicaleffects

(1)Anticoagulation

IncreasingtheactivityofATIII:TheATIII

inhibitingtheactivityoftheactivatedIIa,

IXa,Xa,XIa,XIIa.

Rapidaction,shortduration(2~4h)

Effectivebothinvitroandinvivo.;morerapid