Survivin与肿瘤关系的研究进展.doc

Development of Survivin and Tumor Research JI Yu-bin1,2,3, LIU Guang-da *1,YU Lei1,2,3, LI Hai-jiao 1,YANG Hai-fan1，PANG Lin-lin1 1 Center of Research and Development on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, China; 2.Institute of Materia Medica and Postdoctoral Programme of Harbin University of Commerce, Harbin 150076, China;3.Engineering Reseach Center of Natural Anticancer Drugs,Ministry of Education） Abstract：Objective Survivin was firstly separated in hybridization of Effector Cell Protease Receptor-1(EPR-1) cDNA in human genome by Yale Universitys Ambrosini in 1997,which is member of the inhibitor of apoptosis proteins(IAPS).Unlike other IAP protein,found during embryonic and fetal development,survivin wascompletely down-regulated and undetectable in normal adult tissues,and became prominentlyre expressed in all of the most common cancers.It through includes the cysteine/histidine rod-shaped viral IAP repetition sequence baculoviral IAP repeats(BIRs) the structure territory directly or intervenes Caspases the function to display indirectly its anti-perishes weakly the function, simultaneously it also is in the cell division process the chromosome traveler protein (chromosome passenger protein).There are three approaches by which survivin inhibits the processing of apoptosis:(1)inhibits processing of down stream effector caspase-3,caspase-7and caspase-9 in cell receiving apoptotic stimuls.(2)with the Smac/DIABLO function, sends the XIAP activeness to increase, XIAP through directly affects and restrains its function with caspases, achieved restrains function which perishes weakly; (3) through restrains p53 the function to block perishes weakly the process.Survivin expressed specificity and its function multiplicity.Survivin only expresses in tumor tissues and cannot be found in normal terminally differentiated tissues.This kind of expression is been extremely low the cell cycle strict regulation in the G1 time e