排除 儿童中心静脉置管 合并的菌血症需.pdf

a,b,c,e,f a g Samir S. Shah, MD, MSCE , Kevin J. Downes, BA , Michael R. Elliott, PhD , Louis M. Bell, MDd, Karin L. McGowan, PhDh,i and Joshua P. Metlay, MD, PhDb,e,f,j,k Divisions of a Infectious Diseases and dGeneral Pediatrics and hClinical Microbiology Laboratory, Children’ s Hospital of Philadelphia, Philadelphia, Pennsylvania; Departments of b Epidemiology c Pediatrics j Medicine i Pathology and Laboratory Medicine and Centers for eClinical Epidemiology and Biostatistics and f Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; kVeterans’ Affairs Medical Center, Philadelphia, Pennsylvania; g Department of Biostatistics, University of Michigan School of Public Health, and Survey Methodology Program, University of Michigan Institute for Social Research, Ann Arbor, Michigan 48 h ( c h i l d ) ; ( b a c t e r e m i a ) ; (sepsis); ( c e n t r a l v e n o u s catheterization); (blood culture) 200 5.5 80.5 d51%25% CVC = central venous catheter BSI = bloodstream infection 26% 2 CMBCS = continuous-moni- 14 h 36 h toring blood-culture system HR = hazard ratio 99.2% 36 h 96.6%Cox