网络药理学_药物发现的新思想.pdfVIP

·1472 · 药学学报 Acta Pharmaceutica Sinica 2010, 45 (12): 1472− 1477 网络药理学: 药物发现的新思想 * 刘艾林, 杜冠华 ( 中国医学科学院、北京协和医学院药物研究所, 北京 100050) 摘要: 新药研发是医药产业发展的核心驱动力, 也是社会发展的重要需求, 但近年来, 随着对药物研发要求 的不断提高, 新药研发正面临着巨大困难, 单靶点高选择性的新药研发思想遇到了挑战, 已经显示出发展的局限 性。网络药理学是近年来在单靶点药物研究的基础上提出的新药发现新策略。本文围绕网络药理学的形成基础 和目前研究现状, 探讨网络药理学发展的方向和应用前景, 同时分析网络药理学的局限性和存在的问题, 并通过 与传统中医药学理论和中药复方有效成分组学的思想相比较, 探讨网络药理学在新药研发中的应用。 关键词: 疾病-药物网络; 网络药理学; 网络计算方法; 药物发现 中图分类号: R96 文献标识码: A 文章编号: 0513-4870 (2010) 12-1472-06 Network pharmacology: new guidelines for drug discovery * LIU Ai-lin, DU Guan-hua (Institute of Materia Medica, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100050, China) Abstract : The development of new drug is not only the main driving force for the development of pharma- ceutical industry, but also plays a very important role in the social development. However, with the increasing demands, new drug development is facing great difficulties in recent years. The hypothesis of highly selective single-target is meeting the challenges because of its limitations. Network pharmacology has been one of the new strategies for new drug discovery based on single-target drug research in recent years. This paper focused on the basis of network pharmacology and its research progress, discussed its development direction and application prospects, and analyzed its limitations and problems as well. The app