补髓生血颗粒对于非重型再生障碍性贫血患者造血相关粘附分子CD58及CD11b的影响.docVIP

  补髓生血颗粒对于非重型再生障碍性贫血 患者造血相关粘附分子 CD58 及 CD11b 的 影响#  5 10 15  王金环，孙凤，孙伟正，孙岸弢* （黑龙江中医药大学附属第一医院，哈尔滨 150040） 摘要：目的：观察补髓生血颗粒对于非重型再生障碍性贫血（简称非重型再障，Non-Severe Aplastic Anemia,NSAA）造血相关粘附分子 CD58/LFA-3 及 CD11b 的影响。方法：将 65 例 NSAA 患者分为两组，试验组 34 例，其中肾阳虚型 17 例，肾阴虚型 17 例，应用补髓生血 颗粒治疗，对照组 31 例使用再障生血片治疗，两组均治疗 6 个月，并与 10 例正常人进行比 较。采用流式细胞术（FCM）检测非重型再障患者及正常人骨髓单个核细胞受体 CD58/LFA-3 及 CD11b 表达率的变化。结果：NSA 患者 CD58/LFA-3 及 CD11b 均呈低表达状态，经治疗 后两者均有一定程度调整，其中 CD58/LFA-3 试验组与对照组比较无显著差异，而 CD11b 试验组的调整程度优于对照组，而肾阳虚型患者 CD58/LFA-3 疗后与阴虚型患者比较无显著 差异，CD11b 表达水平则较肾阴虚型患者更易得到纠正。结论：非重型再障患者 CD58/LFA-3 及 CD11b 表达水平均异常，这可能是导致 NSAA 造血衰竭的一个原因。 关键词：贫血；再生障碍性；粘附分子；CD58/LFA-3；CD11b 中图分类号：R2-031 20 Busui Shengxue Granule Effects upon Non-Severe Aplastic Anemia Patients Hematopoietic Adhesion Molecule, CD58 and CD11b WANG Jinhuan, SUN Feng, SUN Weizheng, SUN Antao 25 30 35 40 (First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin 150040) Abstract: Purpose: To observe the effects of Busui Shengxue Granule on non-severe aplastic anemia (NSAA) patients’ CD58/LFA-3 and CD11b. Method: Divide the 65 patients into two groups--experimental group and control group. There are 34 patients in the experimental group, including 17 patients of kidney Yin deficiency and 17 of kidney Yang deficiency. Busui Shengxue Granule will be applied to them. To the 31 patients in the control group, tablet for replenishing blood and treating aplastic anemia is used. All the patients are treated for six months and will be compared with 10 normal persons after the treatment. Apply FCM on patients with non-severe aplastic anemia and normal persons to test the expression’s change of CD58/LFA-3, receptor of bone marrow mononuclear cells and CD11b. Results: NSAA patients’ CD58/LFA-3 and CD11b are in the state of low expression. After the treatment, both CD58/LFA-3 and CD11b change to some extent. And there is no obvious difference between CD58/LFA-3 experimental group and control group. But CD11b experimental group has be