利用脑移位模型预测磁共振功能影像术中移位的初步研究.docVIP

  利用脑移位模型预测磁共振功能影像术中 移位的初步研究# 姚成军，吴劲松，庄冬晓，路俊锋，邱天明* 5 10 15 20 25 30 35 40 （复旦大学附属华山医院神经外科，上海 200050） 摘要：目的 本研究采用薄板样条数学模型来调整脑移位对 BOLD 激活区和锥体束产生的误 差。方法 19 例涉及锥体束的脑占位病变患者和 21 例涉及脑皮层运动区或语言区的脑占位 病变患者，采用 DTI 和 BOLD 技术分别显示锥体束和皮质功能区。利用基于薄板样条的非刚 体配准法计算出脑变形的趋势预测,然后将 DTI 或 BOLD 影像进行关联，即可得到预测的 DTI 或 BOLD 变形后的图像，再将该图像与术中 iMRI 图像融合，从而直观地了解移位后的脑组织、 锥体束或 BOLD 激活区与残余肿瘤的位置和毗邻关系。同时利用 iMRI 影像对预测准确性进行 验证。结果 40 例患者均成功成像并进行融合；脑变形，BOLD 和 DTI 影像变形预测均成功获 得。结论 基于薄板样条非刚体配准算法的数学模型是预测 BOLD 和 DTI 移位的有效方法，预 测准度可满足临床之需求。 关键词：影像融合；术中磁共振；DTI；BOLD；薄板样条；非刚体配准法；脑变形 中图分类号：R651.1+1 Predicting the Shift of BOLD and DTI by Brain Shift Model of iMRI: Laboratory Study YAO Chengjun, WU Jingsong, ZHUANG Dongxiao, LU Junfeng, QIU Tianming (Huashan Hospital, Fudan University, ShangHai 200050) Abstract: Object：In order to solve the brain shift in navigation, we used mathematical models based on thin-plate splines to adjust the navigative errors of DTI or BOLD . Methods: The techniques of DTI and BOLD were used to localize the pyramidal tracts and functional cortex in 19 patients with brain tumors involving pyramidal tracts in high-field MRI and 21 patients with tumors involving motor or linguistic cortex. In this research, pre-operative iMRI and intra-operative iMRI were used respectively for pre-operative and intra-operative data fields, and non-rigid calculation based on thin-plate splines was applied for predicting the tendency of brain shift. When this calculated tendency was integrated into DTI or BOLD images, predictive DTI or BOLD images after brain shift were acquired. Then we integrated these DTI or BOLD images into intra-operative iMRI images so as to visually learn the location and relative relationship of the brain tissue, residual tumor and pyramidal tracts or functional cortex after brain shift .Results: The imaging and integration were of success in total 40 patients. We also successfully acquired the prediction of DTI and BOLD images shift. Conclusions: The mathematical model of non-rigid calcu