甲型H1N1 流感患者外周血细胞计数与病情严重程度的关系研究.docVIP

甲型H1N1流感患者外周血细胞计数与病情严重程度的关系研究 蒋明彦1, 刘国平1，曾建平1*，赵子文2 ，付杰伟 1，刘康 1， 袁光雄1 1 湘潭市中心医院呼吸科,湘潭 411100 2 广州市第一人民医院呼吸内科,广州 510180 【摘要】: 目的 探讨甲型H1N1流感患者外周血细胞计数与病情严重程度之间的关系。方法　将本院300例甲型H1N1流感患者根据病情的严重程度分为普通病例组和重症及危重病例组 ，比较两组外周血细胞计数;采用Logistic回归模型对甲型H1N1流感患者重症及危重病例与外周血细胞计数的相关性进行分析。结果 外周血白细胞数，淋巴细胞数与预后相关(P＜0.05)；用Logistic回归方程对300例甲型H1N1流感患者进行回顾性验证，结合外周血白细胞数、淋巴细胞数对甲型H1N1流感患者中重症及危重病例判断的总正确率为85.1％。该方程的敏感性为70.4％ ，特异性为98.8％ 。结论　外周血白细胞数、淋巴细胞数联合分析能提高对甲型H1N1流感患者中重症及危重病例判断的准确性。 【关键词】: 甲型H1N1流感；重症及危重病例; 外周血细胞计数; Logistic回归模型 A relationship Study between peripheral blood cell counts of patients with H1N1 influenza A and severity of patients condition. JIANG Ming-yan 1, LIU Guo-ping1 , ZENG Jian-ping1 , ZHAO Zi-wen2，1 、Xiangtan Central Hospital，Xiangtan 41110 2 、Guangzhou first people hospital breath internal medicine department, Guangzhou 510180ABSTRACT Objective: To investigate the relationship between peripheral blood cell * 通讯作者：曾建平（J8283174@SOHU.COM） counts of patients with H1N1 influenza A and severity of patients condition. Methods: A total number of 300 patients with H1N1 influenza A from authors hospital were divided into normal-condition group and severe-and-critical-condition group, peripheral blood cell counts of each group were compared. The relationship among condition of patients with severe or critical H1N1 influenza A and patients peripheral blood cell counts was analyzed using step-wise logistic regression model. Results: Counts of peripheral leukocytes and lymphocytes are correlated with patients prognosis (p 0.05). All 300 patients were retrospectively analyzed using step-wise logistic regression model, which shows the overall-accuracy of estimating severe or critical condition using combined analysis of peripheral peripheral leukocytes and lymphocytes counts is 85.1%, sensibility of analysis equation is 70.4%, specificity is 98.8%.Conclusion: Combined analysis of peripheral leukocytes and lymphocytes counts may improve the accuracy of estimating the severe or cri