辅助生殖技术出生儿近期安全性评价.pdfVIP

2010 3 19 3 Prog ObstetGynecol, M arch 2010, Vol19, No3 * 刘风华,何 玲 (广州医学院第三附属医院生殖助孕科, 广州 510150) ! :比较辅助生殖技术(体外受精胚胎移 和卵泡浆内单精子注射)单 胎出生儿与自然妊娠单胎出生儿的出生情况, 评价辅助生殖技术出生儿的近期安全性 : 将 2004年 1月~ 2007年 12月在广州医学院第三附属医院经体外受精( IVF)妊娠 单胎出生儿列为 IVF组, 共 415例; 经卵泡浆内单精子注射( ICSI)妊娠单胎出生儿列为 ICSI组, 共 152例;将同期自然妊娠单胎出生儿列为对照组, 共 8240例比较 3组间低出 生体重早产及出生缺陷的发生率: IVF组低出生体重率早产率及出生缺陷率分 别为 6. 0%11. 8%2. 2%; ICSI组分别为 6. 6%14. 5%2. 0%; 对照组则分别为 5. 9% 10. 3%2. 4% 3组间低出生体重率早产率及出生缺陷率的差异均无统计学意义(P 0. 05):辅助生殖技术单胎出生儿与自然妊娠单胎出生儿的出生情况无明显差异, 不同助孕方式间出生儿的出生结局也无明显差异, 近期评估辅助生殖技术是安全的 ! 生殖技术,辅助;婴儿,新生; 出生缺陷; 安全性 : R715. 8 : A : 1004- 7379( 2010)03- 0179- 03 E valuate th e security of assisted reproductive technology in the near future. L iu Feng hua, H e L ing. R ep roductive M ed ical C enter, the Th ird Aff iliated H osp ital of Guangz hou M ed ical Col leg e, Guangzhou 510150 Ab stract! Objective: To co pare the neonatal outco e of singletons conceived through assisted reproductive technology(ART) with naturally conceived singletons, and evalu ate the security ofART in the short ter .M ethods: A case control studywas conducted on sin gletons born after IVF, ICSI and natural conception at the Third Affiliated Hospital of Guang zhouMedicalCollege fro Jan. 2004 to Dec. 2007. Singletons conceived by IVF were 415, conceived by ICSIwere 152, and naturally conceived singletonswere 8240. Co pared the low birthweight rate, pre ature delivery rate and birth defect rate between the three groups. R e sults: The low birthweight rate, pre ature delivery rate and birth defect rate were 6. 0%, 11. 8%, 2. 2% in the IVF group, 6. 6%, 14. 5%, 2. 0% in the ICSIgroup and 5. 9%, 10. 3%, 2. 4% in the control group, respectively. Therewere no significant differences a ong the three groupsw ith regard to the low birthweight