细胞因子诱导的杀伤细胞治疗难治性淋巴瘤的临床研究.pdfVIP

·970 · 中华实用诊断与治疗杂志第 23 卷第 10 期 ·论 　著 · 细胞因子诱导的杀伤细胞治疗难治性淋巴瘤的临床研究 1 1 2 1 3 4 4 5 5 郭智 ,谭晓华 ,陈丰 ,石宇杰 ,张明 ,张育葵 ,胡碧川 ,纪妍 ,瞿嵘 　　 〔摘要〕　目的:探讨细胞因子诱导的杀伤细胞在难治性淋巴瘤患者中的应用及临床效果 。方法 :8 例难治性淋巴瘤 患者 ,通过血细胞分离机采集外周血单个核细胞 ,培养和扩增细胞因子诱导的杀伤细胞后回输至难治性淋巴瘤患者体 内,评价其疗效 。结果 :细胞因子诱导的杀伤细胞治疗后患者 自觉症状改善 ,影像学复查显示 1 例多发侵犯肿块基本消 失 ,7 例肿块均有不同程度缩小 , T 细胞亚群水平在回输后均有明显升高 。结论 : 细胞因子诱导的杀伤细胞治疗难治性 淋巴瘤患者可改善生活质量 ,不良反应小 ,有较好的临床效果 ,为难治性淋巴瘤提供了一种新的治疗方案 。 　　 〔关键词〕　难治性淋巴瘤 ;细胞因子诱导的杀伤细胞 ;免疫治疗 　　中图分类号 :R733 . 4 　　文献标识码 :A 　　文章编号 :(2009) Cl inical study on the treatment of refractory lymphoma with cytokine induced killer GU O Zhi , TAN Xiaohua , C H EN Feng , et al . Dep art ment of Hematolo gy , General Ho spit al of Beij ing Milit ary A rea , Beij in g 100700 , China 〔Abstract 〕Objective To di scu ss cyto kine in duced killer in ref ractory lymp ho ma p atient s an d t he clinical eff ect . Methods Eight p atient s wit h ref ractory lymp ho ma were collect ed p erip heral bloo d mononuclear cell s wit h bloo d cell sep arator , and t ran sf u sed back aft er t he cyto kine induced killer cell s were cult ured and exp anded . The t herap eutic eff ect wa s evaluat ed . Results The symp to m s were imp roved aft er t reat ment by cyto kine induced killer . One ca se of multip le violation s of t he t umor di sapp eared , t he ot her 7 ca se s reduced in t umor size , and T cell sub set s were obvio u sly rai sed in t he level aft er t ran sf u sion . Conclusion Cyto kine induced killer can imp rove t he qualit y of lif e wit h light adver se reaction and bet t er clinical re sult s in t he t reat ment of ref ractory lymp ho ma . It p rovide s a new