维生素D与癌症研究现状和展望.pdfVIP

第25卷第2期 生命科学 Vol. 25, No. 2 2013年2月 Chinese Bulletin of Life Sciences Feb., 2013 文章编号：1004-0374(2013)02-02 18-13 D 维生素 与癌症：研究现状和展望 李　绵，陈培战，李晓光，王　慧* ( 中国科学院上海生命科学研究院营养科学研究所，上海200031) D 摘　要：维生素 作为一类脂溶性必需维生素参与体内多种生物学过程，具有预防和治疗佝偻病、老年性 D D 骨折等功能。维生素 不仅影响钙、磷的吸收和贮存，近年来研究发现体内维生素 状态与多种肿瘤的发 D D 生发展显著相关，维生素 水平与肿瘤关系成为肿瘤研究领域热点。就维生素 和多种肿瘤如乳腺癌、结 D 直肠癌之间的相关性研究现状和进展进行综述，并针对维生素 在肿瘤发生发展中的分子机制及其临床应 用进行探讨和展望。 D 关键词：维生素 ；癌症 ；乳腺癌 ；结直肠癌 Q565 R73 A 中图分类号： ； 文献标志码 ： Vitamin D and cancer: present status and future prospects LI Mian, CHEN Pei-Zhan, LI Xiao-Guang, WANG Hui* (Institution for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China) Abstract: Vitamin D is a fat-soluble essential vitamin that participates in a variety of biological processes, especially in preventing and treating of rickets and senile fracture. Besides of its effect on the absorption and storage of calcium and phosphorus, experimental data suggest a protective effect of vitamin D on cancer. The relationship between vitamin D and cancer has become a hot topic in cancer research. Here, we briefly review the relationship between vitamin D and a variety of cancers, such as breast cancer and colorectal cancer, and have a discussion on the molecular mechanisms and clinical applications of vitamin D in cancer. Key words: vitamin D