抗菌肽制剂对母猪初乳中免疫球蛋白水平的影响Dietary.pdfVIP

抗菌肽制剂对母猪初乳中免疫球蛋白水平的影响 抗菌肽制剂对母猪初乳中免疫 球蛋白水平的影响 Dietary Supplementation with Antimicrobial Peptides During Pregnancy and Lactation Increases Porcine Colostral Immunoglobulins and Total Proteins 庄燕 皮灿辉 谢晓芳 周冬梅 马轶凡 摘 要 抗菌肽是具有抗菌活性的一类短肽，是宿主天然防御的重要组成部分。目前很多研究致力于将其开发成传统抗生 素的替代品或食品添加剂。在前期研究中，我们观察到在孕期和哺乳期的母猪饮食中添加抗菌肽，包括LL-37、HBD-3和 PBD-1, 可以显著提高母猪初乳总蛋白和IgG的水平，从而降低了母猪死产率，提高了新生仔猪的存活率。 关键词 抗菌肽；免疫调剂；免疫球蛋白；初乳 ABSTRACT　Antimicrobial peptides, as a significant component of innate immunity, have been explored as possible alternatives to conventional antibiotics or dietary supplementations. In the present study we demonstrate that dietary supplementation with AMPs, including LL-37, HBD-3 and PBD-1, during the gestation and lactation of sows significantly elevated colostral IgG and total proteins, which contributes to the increased survival rate of neonatal piglets and stillbirth reduction. KEYWORDS Antimicrobial Peptide; Immunoglobulin; Colostrum 1 Introduction ntimicrobial peptides (AMPs) are evolutionarily with antimicrobial peptides, including LL-37, human Aconserved components of the innate immune system defensin-3 (HBD-3) and porcine defensin-1 (PBD-1), that is the first line of protection in both invertebrate during the gestation and lactation of sows significantly and vertebrate species. They exert broad-spectrum increased the survival rate of neonatal piglets and reduced antimicrobial activities against various microorganisms, the stillbirth rate. However the underline mechanism including bacteria, fungi, certain parasites, and viruses,