细菌, 内毒素, 炎性介质并治——治疗重症脓毒病的新策略.pdfVIP

中国危重病急救医学 1998 年 6 月总第 10 卷第 6 期 3·23 · ·论　著· 细菌、内毒素、炎性介质并治 ——治疗重症脓毒病的新对策 王今达　雪　琳 　　摘要　 目的: 探讨治疗重症脓毒病的新对策。方法: 制作重症 . 脓毒病小鼠模型, 用细菌、内毒 E Co li 素、炎性介质并治的方法治疗, 观察此方法是否能提高重症 . 脓毒病小鼠存活率。结果: 生理盐水 E Co li 加泰能治疗组的存活率为 10% ; “血必净”加泰能治疗组的存活率为95% 。两者比较, P 0 001。结论: 细菌、内毒素、炎性介质并治是治疗重症脓毒病的新对策; 用此方法治疗重症 . 脓毒病小鼠, 能显 E Co li 著提高其存活率。 关键词　新对策　脓毒病　“血必净”　泰能　内毒素　炎性介质 Bacter ia , endotox in , inf lammatory m ediator treated sim ultaneously is a new strategy for the treatm en t of severe sepsis　W ang Ch inta, X ue L in. Institu te of C ritical Care M ed icine , F irst Central H osp ital of T ianj in, T ianj in 300192 　 : . : Abstract Objective To evaluate the new strategy fo r the treatm ent of severe sep sis M ethods To m ake the severe E , Co li sep sis model of mouse, it w as treated by the m ethod of bacteria, endo toxin, in flamm ato ry m ediato r treated sim ultaneously, to observe w hether the survival rate of severe E. Co li sep sis can be imp roved w ith th is m ethod. Results: T he survival rate of severe sep sis, in no rm al saline and ( )