海洋天然产物研究概论.pdfVIP

海洋天然产物研究概述 海洋天然产物研究概述 * 史清文 ，李力更，霍长虹，张嫚丽，王于方 （河北医科大学药学院天然药物化学教研室，河北 石家庄 050017 ） 摘 要：近年来海洋天然产物越来越引起科学家们的注意，在浩瀚的海洋中存在着大量令人激动、 活性独特、结构新颖的次生代谢产物。海洋天然产物已成为发现重要先导药物和新的生物作用机 制的主要源泉。本文对目前海洋天然产物研究概况做简要综述，其中重点介绍大环内酯类和聚醚 类等化合物。 关键词：海洋天然产物化学；海洋药物；研究进展 Outline of Marine Natural Product Research * SHI Qing-wen , LI Li-geng, HUO Chang-hong, ZHANG Man-li, WANG Yu-fang Department of Medicinal Natural Product Chemistry, College of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China Abstract: Ocean is a unique and excellent source that provides a diverse array of intriguing natural products. Marine natural products have demonstrated significant and extremely potent biological activities and have captured the attention of natural products chemists in the past few decades. It is increasingly recognized that a wealth of fascinating natural products and novel chemical entities will play a dominant role in the discovery of useful leads for the development of pharmaceutical agents and has been widely used as useful tool in the study of biological processes. The outline of marine natural product research was summarized concisely and emphasis was focused on the macrolides and polyethers in this paper. Key words: chemistry of marine natural products; marine medicines; research; outline 近一个世纪以来，随着各种色谱技术特别是高效液相色谱技术、结构鉴定技术如各种二维 核磁共振技术和各种串联质谱技术的发展，天然产物化学研究取得了长足的进步，天然产物因 其新颖的结构和特殊的生物活性有的直接成为临床应用药物、有的为合成药物提供了设计模版。 1981 年至2002 年间全球范围公布的877 个新药物实体中，有61% 的药物或直接来源于天然产 [1] 物或者为受天然产物的启发而设