肌腱粘连机制及预防的研究进展.pdfVIP

2013 5 27 5 中国修复重建外科杂志 年 月第 卷第 期 633 · · 肌腱粘连机制及预防的研究进展 姜士超 刘珅 范存义 【摘  要】    目的 综述肌腱粘连机制及预防的研究进展。 方法 广泛查阅近年来肌腱粘连的相关文献，并对其 发生机制及预防的相关研究进行分析总结。 结果 肌腱粘连发生的分子机制主要与TGF-β1、早期生长反应基因 1、基 质金属蛋白酶 9 等的过表达有关。目前预防肌腱粘连的方法主要包括应用药物、屏障、优化康复训练及基因治疗等。以 上方法虽然在实验中取得了较好效果，但是临床应用还有待于证实。 结论 进一步探究肌腱粘连发生的机制和预防方 法，促进临床转化应用，对临床预防肌腱粘连具有重要意义。 【关键词】 肌腱粘连 机制 预防 RESEARCH PROGRESS OF MECHANISM AND PREVENTION OF PERITENDINOUS ADHESIONS/JIANG Shichao, LIU Shen, FAN Cunyi. Department of Orthopaedics, Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R.China. Corresponding author: FAN Cunyi, E-mail: fancunyi888@ 【Abstract 】 Objective To review the research progress of mechanism and prevention of peritendinous adhesions. Methods Recent l iterature about peritendinous adhesions was reviewed, and the results from experiments about the mechanism and prevention of peritendinous adhesions were analyzed. Results The molecular mechanism of peritendinous adhesions is related to overexpressions of transforming growth factor β1, early growth response protein 1, matrix metallopeptidase 9, and so on. The present methods of prevention of peritendinous adhesions include drugs, barrier, optimizing rehabilitation, gene therapy, and so on. These methods have achieved good results in experiments, but the clinical applications have not been confirmed yet. Conclusion It is necessary to pay more attention to the research of mechanism of peritendinous adhesions and methods of its prevention and subsequently to convert them into clinical applications, which is significant to the prevention of peritendinous ad