氧化铁磁性纳米粒子的制备、表面修饰.pdfVIP

第 18 卷 第 10 期 化　学　进　展 Vol. 18 No. 10 2006 年 10 月 PROGRESS IN CHEMISTRY 　Oct. , 2006 氧化铁磁性纳米粒子的制备、表面修饰 及在分离和分析中的应用 赵紫来　卞征云　陈朗星 　何锡文　王彦芬 (南开大学化学系 　天津 300071) 摘 　要 　氧化铁磁性纳米粒子通过表面化学修饰得到无机、有机或聚合物壳包覆在其表面。其中的壳 结构既具有生物适应性 ,又具有可键合生物分子如细胞、蛋白质、酶、抗体和核酸的活性基团 ,而核具有磁性 特性。本文总结了氧化铁磁性纳米粒子的制备方法 ,介绍了其表面化学修饰及在分离和分析应用的最新 进展。 关键词 　氧化铁 　磁性纳米粒子 　制备 　表面修饰 　磁性分离 　生化检测 ( ) 中图分类号: O6114 ; O61481 ; O6526 　文献标识码 : A 　文章编号 : 1005281X 2006 Synthesis and SurfaceModifications of Iron Oxide Magnetic Nanoparticles and Applications on Separation and Analysis Zhao Zilai 　Bian Zhengyun 　Chen Langxing 　He Xiwen 　Wang Yanfen (Department of Chemistry , Nankai University , Tianjin 300071 , China) Abstract 　Iron oxide magnetic nanoparticles with biocompatibility and functional coatings via appropriate surface chemistry approaches have been used for immobilization of cells ,proteins ,enzymes ,antibodies ,oligonucleotides and drugs through covalent bonding or adsorption. The surfacemodified magnetic nanoparticles have been widely used in biological and biomedical areas such as immobilization of biomolecules ; separation of metal ions , cells , proteins , DNA ; immunoassay , biochemical analysis and magnetic resonance imaging (MRI) probes. In this paper , preparation methods , surface modification approaches and analytical applications of iron oxidebased magnetic nanoparticles are reviewed. Key words 　iron oxide ; magnetic nanoparticles ; synthesis ; surface modification ; magnetic separation ;