多肿瘤标志物蛋白芯片检测系统在肺癌诊断中的临床意义.pdfVIP

窑2516 窑 南方医科大学学报(JSouthMedUniv )2010;30(11 多肿瘤标志物蛋白芯片检测系统在肺癌诊断中的临床意义 梁 茱袁王海枫袁吴爱祝袁蔡俊宏渊海南省人民医院中心实验室袁海南海口570311冤 摘要院 目的 探讨多肿瘤标志物蛋白芯片检测在肺癌诊疗中的应用价值遥 方法 采用蛋白芯片技术检测肺癌患者308 例尧 肺部良性病变患者218 例尧 健康体检者250 例血清中的 12种肿瘤标志物渊CA199尧NSE尧CEA尧CA242尧Ferrtin尧 茁-HCG尧AFP尧f-PSA尧PSA尧CA125尧HGH尧CA153冤水平遥 结果 肺癌组阳性率为72.4%袁显著高于良性病变组的22.0%和 健康对照组的5.6%渊P0.01冤曰不同病理类型的肺癌患者阳性率存在差异袁腺癌中CEA尧CA125尧CA153 的阳性率和含量 明显高于鳞癌渊P0.05冤袁有淋巴结转移组的阳性率71.9%袁明显高于无淋巴结转移组的52.1%渊P0.05冤遥 结论多肿瘤 标志物蛋白芯片检测系统对肺癌的辅助诊断和疗效监测有较高的临床价值遥 关键词院肿瘤标志物曰蛋白芯片曰肺肿瘤 中图分类号院R730.43曰R734.2 文献标志码院A 文章编号院1673-4254渊2010冤11-2516-03 Clinical value of multi-tumor markers protein biochip in the diagnosis of pulmonary carcinoma LIANGZhu,WANGHai-feng,WUAi-zhu,CAIJun-hong DepartmentofCentralLaboratory,HainanProvincialPeoplesHospital,Haikou570311,China Abstract: ObjectiveToassessthevalueofmulti-tumormarkersproteinbiochipinthediagnosisandtherapyofpulmonary carcinoma. MethodsTwelvetumormarkers(CA199,NSE,CEA,CA242,Ferrtin, 茁-HCG,AFP,f-PSA,PSA,CA125,HGH, andCA153 )weredetectedusingproteinchipin308patientswithpulmonarycarcinoma, 218withbenignlunglesionsand 250healthysubjects. ResultsThepositivityratewas72.4%inpulmonarycarcinomacases, obviouslyhigherthanthatinthe benigncases(22.0%, P0.01 )andhealthysubjects(5.6%, P0.01). Thepositivityratesdifferedsignificantlybetweenthe pulmonarycarcinomacasesofdifferentpathologicaltypes.ThepositivityratesofCEA,CA125,andCA153weresignificantly higherinadenocarcinomacasesthaninsquamouscarcinomacases (P0.05), andalsohigherincaseswithlymph node metastasisthaninthosewithout (71.9%vs 52.1%, P0.05). ConclusionProteinbiochipcontainingmultipletumormarkers providesvaluableassistanceinthediagnosisandtherapeuticeffectmonitoringofpulmonarycarcinoma. Keywords:tumormarker;proteinchip;lungneoplasms 肿瘤标志物单指标检测在临床上已应用多年袁但 例为2005~2007 年的体检者袁体检中未发现疾病袁男 存在检出率低及费用高的缺点袁蛋白芯片是一