An Updated GA Signaling 'Relief of Repression' Regulatory Model.pdfVIP

An Updated GA Signaling 'Relief of Repression' Regulatory Model.pdf

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MolecularPlant ·Volume4 ·Number4 ·Pages601—606 ·July2011 REVlEW ARTICLE AnUpdatedGA SignalingJReliefofRepression, RegulatoryModel Xiu.HuaGao,Sen-LinXiao,Qin-FangYao,Yu-JuanWangandXiang-DongFu’ StateKeyLaboratoryofPlantCellandChromosomeEngineering.InstituteofGeneticsandDevelopmentalBiolog~ChineseAcademyofSciences,Beijing, 100101,China ABSTRACT Gibberellicacid(GA)regulatesmanyaspectsofplantgrowthanddevelopment.TheDELLAproteinsactto restrainplantgrowth,andGA relievesthisrepressionbypromotingtheirdegradationviathe26Sproteasomepathway. TheelucidationofthecrystallinestructureoftheGA solublereceptorGID1proteinrepresentsanimportantbreakthrough forunderstandinqthewayinwhichGA isperceivedandhow itinducesthedestabilizationoftheDELLAproteins.Recent advanceshaverevealedthattheDELLAproteinsareinvolvedinprotein—proteininteractionswithinvariousenvironmentaI andhormonesignalingpathways.1nthisreview,w ehighlightourcurrentunderstandingofthereliefofrepressionmodeI thataimstoexplaintherole0fGAandthefunctionoftheDELLAproteins,jncorporatjngthemanyaspectsofcross-talk showntoexistinthecontroIofplantdevelopmentandtheresponsetostress. Keywords: GA;DELLA;repression;cross-talk;interaction. 1NTRODUCTlON 2008;FengetaJ.,2008;de LucasetaI.,2008;Ubeda—TOmas GA isamemberofalargefamilvoftetracy¨cditerpenoids;it eta1.,2009;ArnaudetaI.,2010;HouetaI.,201O).Thispresent affects many aspects of plant growth and development, review summarizesrecentimprovementsinourunderstanding including germination,stem and hypocotylelongation,and ofthe reIiefofrepression model(JiangandFu,2007;Hou the induction offlowering (Sun andGubler,2004;Davi~re etaI.,201O),whichdescribeshow GA andDELLA proteins eta1..2008).ThekeycomponentsofGA signaling inboth togethermoduIatethecontroIofplantgrowt h. Arabidopsisthaliana and rice,which havebeen identified usingmutationanaly

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