Toll样受体4与病毒感染的研究进展.pdfVIP

第23 卷 第1 期 生命科学 Vol. 23, No. 1 20 11 年1 月 Chinese Bulletin of Life Sciences Jan., 20 11 文章编号：1004-0374(2011)01-0063-07 Toll样受体4与病毒感染的研究进展 1,2 1 汤贤英 ,李　晖 * ( 1 武汉大学医学部病毒学研究所暨病毒学国家重点实验室，武汉4 3 00 7 1 ； 2 遵义医学院免疫学教研室，遵义563003) 摘 要：Toll 样受体4(TLR4)是固有免疫系统中能够识别病原相关分子模式的受体家族成员，可识别革 兰氏阴性菌的脂多糖( L P S ) 而在细菌感染性疾病的发生中起重要作用。近年来越来越多的研究发现， TLR4 还广泛参与病毒感染性疾病的发生和病毒的免疫逃逸，由于其信号转导通路的独特性和细胞定位的 可变性，再次引起人们极大的研究兴趣。该文将介绍TLR4 的生物学特性、信号转导通路及TLR4 与病 毒感染的最新研究进展。 关键词：T L R 4 ；信号转导通路；病毒感染 中图分类号：R 3 92 ；R 3 7 8　　文献标识码：A Toll-like receptor 4 and viral infection 1,2 1 TANG Xian-Ying , LI Hui * (1 State Key Laboratory of Virology, Institute of Medical Virology, School of Medicine, Wuhan University, Wuhan 43007 1, China; 2 Department of Immunology, Zunyi Medical College, Zunyi 563003, China) Abstract: Toll-like receptor 4 (TLR4) is one of the members of TLRs, which can recognize pathogen-associated pattern molecules and activate innate immunity and acquired immunity . TLR4 plays a critical role in bacterial infections by recognizing lipopolysaccharide (LPS). However, there are accumulating evidences indicating that TLR4 involves in viral infections and contributes to the immune escape of viruses. Moreover, the unique TLR4 signaling pathways and its cellular localization aroused our interest. Here we will review the most recent progress on TLR4, TLR4 signaling and viral infections. Key words: TLR4; TLR4 signaling pathway; viral infection 病毒通过侵入固有免疫系统诱导免疫应答或逃 differentiation pr