功能性消化不良患者血清胃促生长素水平与焦虑抑郁评分的关系.pdfVIP

168 Medical Science Journal of Central South China,March2013,Vol.41,No.2 文章编号:2095-1116(2013)02-0168-03 ·临床医学· 功能性消化不良患者血清胃促生长素水平与 焦虑抑郁评分的关系 曾跃飞,吴摇 青 (南华大学附属南华医院消化内科,湖南衡阳421002) 摘摇 要:摇 目的摇 探讨功能性消化不良(FD)患者血清胃促生长素(Ghrelin)水平与焦虑抑郁评分的关系。 摇 方法摇 采用ELISA 法测定42例功能性消化不良患者和42例健康体检人群(对照组)空腹血清Ghrelin 水平,以焦 虑自测量表(SAS)和抑郁自测量表(SDS)对两组人群进行焦虑抑郁评分。 摇 结果摇 功能性消化不良患者血清Gh鄄 relin水平显著低于对照组(P0.01),功能性消化不良患者SAS和SDS评分均显著高于对照组(P 0.01),血清 Ghrelin水平与SAS和SDS评分均呈负相关(r= -0.68,P0.01;r= -0.63,P0.01)。 摇 结论摇 功能性消化不良 患者血清Ghrelin水平与焦虑、抑郁评分呈负相关。 关键词:摇 功能性消化不良;摇 胃促生长素;摇 焦虑;摇 抑郁 中图分类号:R57摇 摇 摇 文献标识码:A The Correlation Between Serum Ghrelin Levels and Score of Anxiety and Depression in Patients With Functional Dyspepsia ZENG Yuefei,WU Qing (Department of Gastroenterology,Affiliated Nanhua Hospital,University of South China, Hengyang,Hunan421002,China) Abstract:摇 Objective摇 ToinvestigatethecorrelationbetweenserumGhrelinlevelsandscoreof anxiety anddepression in patientswithfunctional dyspepsia.摇 Methods摇 SerumGhrelinlevelsof42 casesof patientswithfunctional dyspepsiaand 42 cases of healthy peoplewere measured by ELISA.Self鄄rating anxiety scale(SAS) and self鄄rating depression scale(SDS) were usedto scoreanxiety anddepressionof thetwogroups.摇 Results摇 SerumGhrelinlevelsof patientswithfunctional dys鄄 pepsiawere significantly lower than the control group(P 0.01),anxiety and depression scores in patients with functional dyspepsiawere significantly higher than thoseinthecontrol group(P0.01),anegativecorrelation (r= -0.68,P0.01;r = -0郾63,P0.01) has been identified among the Scores for SD