复合骨形成蛋白和碱性成纤维细胞生长因子的双相陶瓷样生物活性骨修复指骨缺损.pdfVIP

中国组织工程研究与临床康复 笳 74眷 47崩 2010—11—19出版 JournalofClinicalRehabilitative~ssueEngineeringResearch November19,2010 Vo1．14，No．47 复合骨形成蛋白和碱性成纤维细胞生长因子的双相陶瓷样生物活性骨 修复指骨缺损☆ 王福科’，李彦林 ，王国梁 ，曹 彬 ，李晓林 ，陈建明 ，金耀峰 ，王永年 Biphasicceramic-likebioactivebonecompoundedbybonemOrph0genetlcproteinandbasic fibroblastgrowthfactortorepairfingerbonedefects WangFu．ke’LiYan-fin。WangGuo．1iang。CaoBin。LiXiao．1in ，ChenJian—ming ，JinYao—feng ．WangYong．nian。 ， ． ， ， Abstract BACKGROUND：Biphasicceramic—likebioactivebonecompoundedbonemorphogeneticprotein(BMP)andbasicfibroblast DepadTnentofHead growthfactor(bFGF)hasboneconductionfunction，itcartinducestemcellstodifferentiateinotosteoblastsandhavebecome andNeckSurge D‘epartmentof oneofjdealbonegraftsubstitutesforrepairingbonedefects． Orthopa edics．The 0BJECTIVE：Toexplorethebiphasicceramic—likebioactivebonecomplexofBMPandbFGFintheclinicalrepairofbone FirstA币Bated phalanxdefect． HospitaIofKunming Medice lCollege， METHODS：Tenenchondromapatients．atameanageof33yearswereselected．Thetumorsizewasfr0m 0．3cm x0．3cm x Kunming 650032， 0．3cm ot 1．0cm x0．5cm x0．5cm；tumorswerelocatedintheaffe~edfingerboneandperformedtumorcure,age．tumor YunnanProvince． cavitieswerestuffedwithbiphasicceramic·likebioactivebone．foIlowedbyconventionalwoundsuture；Thepostoperativewound China healing．1ocalinflammation．rejection，systemictoxicity，tumorcavityhealingandrecoveryoflimbfunctionwereobservedafter W angFuke☆ ． operation．