气相色谱法测定伊潘立酮中丙酮、乙醇等多溶剂残留量.pdfVIP

《现代仪器》 2012 年 第 18 卷 第 1 期 研究报告 气相色谱法测定伊潘立酮中丙酮、乙醇等 多溶剂残留量 GC determination of 6 kinds of residual solvents in Iloperidone 摘  要  目的 ：建立毛细管气相色谱法测定伊潘立酮中6 种有机残留溶剂的方法。 谢艳丽1,2 3 1,2   谭 曜   周雪晴 方法 ：采用DB -1701 （30m ×0.32mm ×1.0 μm ）毛细管柱，程序升温 ：60 ℃保持 4 1,2 成 一   赵振东 1min, 然后以6℃/min 的升温速率升至83℃，保持8min ，再以20℃/min 的升温速率 1, 2, 3 3 Xie Yanli   Tan Yao 升至240℃，保持5min 。以DM SO 为溶剂，正丁醇为参比物，用校正相对保留时间 1, 2 3 Zhou Xueqing   Cheng Yi (RART) 定性。结果 ：各溶剂能得到较好的分离，精密度、线性关系良好，6 种溶剂 Zhao Zhendong1, 2 的平均回收率范围为92.02%~ 107.83% ，RSD 值为0.40%~4.56%。结论：本方法简便、 准确、灵敏，适合用于伊潘立酮中多种残留溶剂同时测定。 （1.海南省精细化工重点实验室  海 关键词  伊潘立酮 气相色谱法 残留溶剂 口  570228；2. 海南大学分析测试中 心  海口  570228；3.宁波出入境检 验检疫局  宁波  815012；4. 海南大 Abstract Objective: To establish a method for determination of the residues of 6 kinds of 学材料与化工学院  海口  570228） solvents in Iloperidone by caplillary gas chromatography. Method : The six organic solvents (1. Hainan Provincial Key Lab of Fine were separated on a DB-1701(30m×0.32mm×1.0μm) using programmable increased Chem, Haikou 570228; 2. Chemi- temperature. The column temperature is initially maintained at 60℃ for 1 min and then up cal Analytical and Testing Center of to 83℃ at the rate of 6 ℃/min for 8 min, and eventually raised to 240℃ at the rate of 20 Hainan University, Haikou 570228; ℃/min for 5 min. The samples were dissolved in DMSO with 1-butanol as the reference, 3. Ningbo Entry-exit Inspection and the relative adjustment retention time (RART) was applied to manipulate the qualitative and Quarantine Bureau of P.R.C, analysis. Results : Each solvent was