【化学工程与工艺专业】【毕业设计+开题报告+文献综述】罗匹尼罗中间体2-甲基-3-硝基苯乙酸的合成.docVIP

（20 届） 毕业设计 罗匹尼罗中间体2-甲基-3-硝基苯乙酸的合成 摘要：2-甲基-3-硝基苯乙酸是合成罗匹尼罗的一种重要中间体。本文主要研究了以2-甲基-3-硝基苯甲酸为原料，经过缩合，还原，溴代，取代，水解五步反应制得目标产物2-甲基-3-硝基苯乙酸，总收率为54.19%，并对目标产物进行了熔点和核磁氢谱表征。 关键词：2-甲基-3-硝基苯乙酸；合成；工艺； Abstract: 2-methyl-3-nitrophenyl acetic acid is an important intermediate of Ropinirole. In this paper 2-methyl-3-nitrophenyl acetic acid was synthesized from 2-methyl-3-nitrobenzoic acid as raw material, through condensation, reduction, bromination, substitution and hydrolysis five steps to attain the target product , the total yield was 54.19%. In addition, its structures has been determined by melt point and 1HNMR data. Key Words：2-ethyl-3-nitrophenyl acetic acid; Synthesis; Technology 目 录 摘要................................................................................................................................................ Abstract.............................................................................................................................................Ⅱ 1 绪论............................................................................................................................................ 1.1 课题背景......................................................................................................................... 1.2 2-甲基-3-硝基苯乙酸合成方法...................................................................................... 1.2.1 以2-甲基-3-硝基苯甲醛为原料合成..................................................................... 1.2.2 2-甲基-3-硝基苯甲醛微波法合成..........................................................................2 　实验部分................................................................................................................................ 2.1　 仪器............................................................................................................................... 2.2　 药品............................................................................................................................... 2.3　实验内容...........