矢车菊-3-葡萄糖的抗癌效应研究进展.pdfVIP

※专题论述 食品科学 2013, Vol.34, No.13 329 矢车菊-3-葡萄糖的抗癌效应研究进展 1,2 2 1,* 陈 亮 ，辛秀兰，袁其朋 (1.北京化工大学 化工资源有效利用国家重点实验室，北京 100029；2.北京电子科技职业学院生物工程学院，北京 100029) 摘  要：花色苷是一类天然的黄酮类化合物，广泛分布在人们日常饮食的水果蔬菜中。大量的流行病学与动物实验 研究表明花色苷具有癌症化学预防作用。本文总结了在大多数浆果及相关产品中分布最普遍、含量高的花色苷-矢 车菊-3-葡萄糖苷的抗癌效应，这种效应主要通过抗氧化、激活Ⅱ相解毒酶、抗细胞增殖、诱导细胞凋亡、抗炎效 应、抗血管生成、抗细胞侵入、诱导细胞分化等机制来发挥，本文概述了矢车菊-3-葡萄糖苷的癌症预防效应。 关键词：花色苷；矢车菊-3-葡萄糖苷；抗癌效应 Research Progress in Anticancer Effect of Cyanidin-3-glucoside 1,2 2 1,* CHEN Liang ，XIN Xiu-lan ，YUAN Qi-peng (1. State Key Laboratory of Chemical Resource Engineering, Beij ing University of Chemical Technology, Beij ing 100029, China ； 2. College of Bioengineering, Beij ing Polytechnic, Beij ing 100029, China) Abstract ：Anthocyanins are a group of naturally occurring flavonoid compounds, which is widely available in fruits and vegetables in human diets. A lot of epidemiological and animal experiments have demonstrated that anthocyanins may contribute to cancer chemoprevention. In this article, we summarize the anti-cancer effects and the mechanisms of anthocyanins and cyanidin-3-glucoside (C3G) in berries and related food products on several key steps: antioxidant effects, enzyme activation, anti-cell proliferation, apoptosis induction, anti-inflammation, anti-angiogenesis, anti-invasiveness, and differentiation induction. This review provides a molecular view of cyanidin-3-glucoside contributing to cancer chemoprevention. Key words ：anthocyanins；cyanidin-3-glucoside ；anti-cancer effect 中图分类号：TS255.1 文献标志码：A 文章编号：1002-6630(2013)13-0329-05 doi: 10.7506/spkx 1002-6630-20 1