阿托伐他汀强化治疗对非ST段抬高急性心肌梗死患者的抗炎、抗心肌缺血作用.DOCVIP

临床医学论文-阿托伐他汀强化治疗对非ST段抬高急性心肌梗死患者的抗炎、抗心肌缺血作用 【摘要】? 目的： 探讨阿托伐他汀强化治疗对非ST段抬高急性心肌梗死（NSTEMI）患者的抗炎、抗心肌缺血作用。方法： 选择93例NSTEMI患者，随机分为两组，治疗组47例，给予阿托伐他汀钙30～40 mg/d口服；对照组46例，给予阿托伐他汀钙10 mg/d口服，疗程均为9个月。观察两组患者治疗前、后的临床疗效、心电图（EKG）心肌缺血、C反应蛋白（CRP）及血脂改变情况。结果： 两组患者治疗前后低密度脂蛋白胆固醇(LDL-c)、三酰甘油(TG)、总胆固醇(TC)明显下降，差异有统计学意义(P0.01)；治疗组治疗后CRP,LDL-C,TG,TC较对照组下降明显(P0.01)，临床症状改善组间差异有统计学意义(P0.01)，EKG示心肌缺血明显改善、缺血事件明显减少，差异亦有统计学意义(P0.01)。结论： 阿托伐他汀强化治疗效果良好，具有抗炎、抗心肌缺血作用。他汀类药物强化治疗对防治NSTEMI有重要意义。 【关键词】? 阿托伐他汀； 强化治疗； 非ST段抬高急性心肌梗死 　　［Abstract］? Objective: To explore the anti-inflammatory and anti-myocardial ischemic effects of Atorvastatin intensive treatment towards non-ST elevation acute myocardial infraction （NSTEMI）.Methods： All 93 NSTEMI patients choosing in random were divided into two groups.Intensive treatment group(47 cases)chose Atorvastatin made in? Huirui Company.It was taken orally 30～40 mg/d.The common treatment group(46 cases) was taken orally 10 mg/d.The course of treatment was nine months. Results： Compared with the past the LDL-C,TG,TC in these two groups fell obviously(P0.O1).Compared with the past the LDL-C,TG,TC， C-reactive protein（CRP） in the intensive treatment group fell obviously(P0.01).The abnormity in clinical symptom alleviatition and EKG recording ischemic alleviated was also significant(P0.01).EKG recorded ischemic related events was lower than that in common group(P0.01).? Conclusion： Atorvastatin intensive treatment had the anti-inflammatory and anti-myocardial ischemic effect. It had important meaning in the prevention and cure of NSTEMI with tatin drugs. 　　［Key words］? atorvastatin intensive； treatment； non-ST elevation acute myocardial infraction 　　多年来，各种大规模前瞻性随机双盲临床试验证实，他汀类药物可显著降低急性冠状动脉综合征（ACS）事 件，成为ACS不可缺少的治疗手段，尤其是强化治疗达标，使ACS患者获益更大。我们对47例非ST段抬高急性心肌梗死(non-ST elevation acute myocardial infraction， NSTEMI)患者给予阿托伐他汀强化治疗，观察患者临床疗效、心电图（EKG）心肌缺血、C反应蛋白（CRP）及血脂改变情况。现将结果报告如下。 　　1? 对象与方法 　　1.1? 病例?? 　　选择我院心血管内科病房2000年1月～2007年6月收治的NSTEMI患者93例，诊断符合以下条件：(1)心绞痛时间超过 30 min；(2)EKG出现多导联持续性ST