左乙拉西坦的对部分癫痫患者认知功能及情绪影响的研究.docVIP

左乙拉西坦对部分性癫痫患者认知功能及情绪影响的研究 张建磊*，李郭飞，常娜，王朝辉，刘大建，贺维亚 （河南大学淮河医院神经内科，河南 开封，475000） 摘要目的：探讨左乙拉西坦对癫痫患者认知功能及情绪的临床影响。方法：选择同期部分性癫痫患者62例，随机分为卡马西平组(n=30例)和左乙拉西坦组(n=32例)，卡马西平组患者给予卡马西平治疗，左乙拉西坦组患者给予左乙拉西坦治疗，治疗第4周、8周、12周、16周比较两组患者蒙特利尔认知评估量表(MoCA)、焦虑自评量表(SAS)和抑郁自评量表(SDS)情况。结果：两组患者治疗第8周、12周、16周的MoCA评分比较，差异均具有统计学意义(P＜0.05)，左乙拉西坦组优于卡马西平组；SAS评分和SDS评分比较，差异不具有统计学意义(P0.05)。结论：在部分性癫痫患者的药物治疗过程中，左乙拉西坦对患者认知功能的改善优于卡马西平，但对情绪的影响无明显差异。 关键词：左乙拉西坦；卡马西平；癫痫；认知功能；情绪影响 The Clinical Study about Levetiracetam of Cognitive Function and Emotional Influence in the Patients with partial Epilepsy ZHANG Jian-lei，LI Guo-fei，CHANG Na，WANG Zhao-hui，LIU Da-jian, HE Wei-ya (Department of Neurology, Huaihe Hospital of Henan University,Kaifeng,475000,China) ABSTRACT Objective: To investigate the clinical influence about Levetiracetam（LEV）of cognitive function and emotional influence in the patients with partial epilepsy. Method: 62 patients with partial epilepsy were collected. 30 patients were treated by carbamazepine（CBZ )while 32 patients were treated by Levetiracetam. MoCA Scale, SAS Scale and SDS Scale was detected at the end of 4 weeks, 8 weeks, 12 weeks and 16 weeks treatment. Result:There was significant difference (P＜0.05) in the MoCA score after 8 weeks, 12 weeks and 16 weeks treatment, which was better in LEV group than CBZ group. There was no significant difference(P0.05) in the SAS Scale and SDS Scale after 4 week, 8 weeks, 12 weeks and 16 weeks treatment, the LEV group showed no better result than the CBZ group. Conclusion: In the process of treating the patients with partial epilepsy by drug, Levetiracetam is superior to carbamazepine on the improvement of cognitive function, while the influence on mood was no better than carbamazepine. Key words: Levetiracetam; Carbamazepine; Partial epilepsy; Cognitive Function; Emotional influence 癫痫是临床常见的慢性神经系统疾病，与癫痫相关的认知及情感障碍一直是医生和患者非常关注的问题。癫痫患者伴发的认知、情感障碍与发病原因、起病年龄、病灶部位、发作类型、持续时间、发作频率及抗癫痫药物等多种因素均有关[1]，但由于抗癫痫药物是可触及、可选择因素，且为目前治疗癫痫最主要方法而受到更多的关注。传统抗癫痫药物对认知功能的影响已有较多研究报道，