B7H4和 CA125在卵巢癌早期诊断中的应用价值.pdfVIP

- 104 - 肿瘤药学 2013 年 4 月第 3 卷第 2 期　Anti-tumor Pharmacy, April 2013, Vol. 3, No. 2 ●基础研究● B7-H4 和 CA125 在卵巢癌早期诊断中的应用价值 陈素梅 （贺州市人民医院，广西　贺州，542800 ） 摘要 ：目的　分析和探讨 B7-H4 以及 CA125 在卵巢癌早期诊断中的应用价值。方法　采用 ELISA 双抗体夹 心法检测卵巢癌患者及健康女性血清中 B7-H4、CA125 的含量，分析其含量与卵巢癌分期、治疗效果的关系，研究 其在卵巢癌早期诊断中的价值。结果　卵巢癌患者血清 B7-H4、CA125 分子水平显著高于健康对照，且随癌症分 期的进展而升高（ 0.05），血清 B7-H4、CA125 分子水平与卵巢癌治疗效果相关。B7-H4 分子与 CA125 分子联合 P 应用于卵巢癌诊断时，可明显提高诊断的敏感度与特异度。结论　将 B7-H4 与 CA125 联合检测应用于卵巢癌早 期诊断可显著提高诊断的敏感性和特异性，值得临床深入研究和推广。 关键词 ：卵巢癌；早期诊断；B7-H4；CA125 中图分类号：R737.9　文献标识码：A　文章编号：2095-1264（2013）02-0104-03 doi：10.3969/j.issn.2095-1264.2013.024 Application Value of B7-H4 and CA125 in the Early Diagnosis of Ovarian Cancer Chen Sumei (People ’s Hospital of Hezhou city, Hezhou, Guangxi, 542800, China) To analysis the application value of B7-H4 and CA125 in the early diagnosis of ovarian cancer. Abstract: Objective Methods The serum levels of B7-H4 and CA125 in ovarian cancer patients and healthy women were detected by ELISA double antibody sandwich assay. The relationship between the levels of B7-H4 and CA125 and ovarian cancer staging, treat- ment effect was analyzed and its value in the early diagnosis of ovarian cancer was evaluated. Results The serum B7-H4, CA125 molecular level of patients with ovarian cancer was significantly higher than those of healthy controls and increased with the stage of cancer (P 0.05). The serum level of B7-H4 and CA125 was related with ovarian cancer therapeutic effect. B7-H4 in combination with CA125 used in the diagnosis