Foxp3与恶性肿瘤治疗关系的研究进展.pdfVIP

608 中国肿瘤临床2014年第41卷第9期 ChinJClinOncol2014,Vol.41,No.9 Foxp3与恶性肿瘤治疗关系的研究进展 薛 强 综述 郝继辉 审校 摘要 叉头型转录因子3（forkhead boxprotein 3，Foxp3）被认为是来源于胸腺以及外周的调节性T细胞的标志性分子。 Foxp3虽然在除胸腺和脾以外的组织中有较少程度的表达，最新发现Foxp3可以表达于多种肿瘤细胞，并且与恶性肿瘤的发生、发 展以及预后具有一定的关系。Foxp3已经成为近来恶性肿瘤治疗研究的热点之一，以期能够为恶性肿瘤的治疗带来新的契机。 关键词 叉头样转录因子3 调节性T细胞 恶性肿瘤 治疗 doi:10.3969/j.issn.1000-8179 Progress on the relationship between Foxp3 and malignant tumor treatment Qiang XUE, Jihui HUI Correspondence to: Jihui HAO; E-mail: xueq2012@126.com Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin 300060, China. + + Abstract The expression of transcription factor forkhead box protein 3 (Foxp3) is predominantly restricted to the CD25 CD4 population in both the thymus and periphery. Limited evidence indicated that Foxp3 is also expressed, albeit to a lesser extent, in the tis- sues outside of the thymus and spleen. However, recent studies showed that Foxp3 is expressed in many tumor cells, and has a definite relation with the occurrence, progress, and prognosis of malignant tumors. Foxp3 has become a popular topic in research on malignant tumor treatment, thereby bringing a new turning point for malignant tumor therapy. Keywords: Foxp3, Regulatory T cells, malignant tumor, therapy 机体为了保持免疫系统的稳定状态，防止免疫系 各异的大家族，主要成员包括Foxp1、Foxp2、Foxp3和 统过度激活导致的自身免疫性损害，进化了一套较为 Foxp4。而Foxp3首次发现于Scurfy突变小鼠，cDNA全 ［3］ 完备的免疫调控系统。调节性T细胞（RegulatoryT 长为3739bp 。 cells，Treg）是参与免疫抑制机制的重要T细胞亚群。 人类Foxp3基因定位于Xp11.23，包含11个外显 ［1］ 近年研究 表明，叉头样转录因子3（forkheadboxpro⁃ 子和10个内含子，cDNA全长为1869bp，其可编码产 te