MMP3在肿瘤发生发展中作用的新进展★.pdfVIP

- 166 - 肿瘤药学 2013 年 6 月第 3 卷第 3 期　Anti-tumor Pharmacy, June 2013, Vol. 3, No. 3 ●综　　述● MMP3 在肿瘤发生发展中作用的新进展★ 胡　涂，曾乐平（综述），黄菊芳* （审校） （中南大学基础医学院人体解剖学与神经生物学系，湖南　长沙，410013 ） 摘要 ：基质金属蛋白酶 3（matrix metalloproteinase3, MMP3）是 MMPs 家族的主要成员之一，其前肽区（propeptide, Pro）和铰链（hinge, H）之间的具有 Zn2+ 活性位点的接触反应性核团（catalytic domain）是其核心反应部位。MMP3 在机 体内表达的变化和活性的异常参与了多种疾病的病理过程，特别是肿瘤的发生与发展过程。本文将从 MMP3 的结构、 功能、生物化学特性及其在肿瘤发生发展中的作用等方面综述其最新研究进展。 关键词 ：MMP3；TIMP 1；基因多态性；肿瘤 中图分类号：R737.9　文献标识码：A　文章编号：2095-1264（2013）03-0166-06 doi：10.3969/j.issn.2095-1264.2013.040 Research Progress on the Role of MMP3 in the Development of Tumor ★ Hu Tu, Zeng Leping, Huang Jufang* (Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, Hu- nan, 410013, China) Abstract: Matrix metalloproteinase 3 (MMP3) is attached to the family of Matrix metalloproteinases (MMPs). And the cata- lytic domain, which is located between the propeptide (Pro) and the hinge and has an active site with Zn2+, is the cardinal active site of MMP3. Its change in gene expression and its abnormal activity contribute to the pathologic processing of many diseases, especially to the development of tumor. This review is aimed at introducing and elaborating MMP3 through its structure, func- tion, biochemistry and its contribution in tumor progression. Key words: Matrix metalloproteinase 3; Tissue inhibitor of metalloproteinase 1; Gene polymorphism; Tumor 前言 metalloproteinases, MMPs）是一系列 Zn2+ 依赖型肽链 　　基质金属蛋白酶 3 （matrix metalloproteinase3, 内切酶，最早由 Gross 和 Lapiere 在 1962 年发现并 MMP 3 ）的功能比较特殊，可以降解、重塑细胞