Notch3信号通路与卵巢癌发生发展关系的研究.pdfVIP

中国癌症杂志 2013年第23卷第12期 《 》 CHINA ONCOLOGY 2013 Vol.23 No.12 1001 Notch3信号通路与卵巢癌发生发展 关系的研究 1 2 1 刘杨 　杨恭 　臧荣余 1. 复旦大学附属肿瘤医院妇瘤科，复旦大学上海医学院肿瘤学系，上海 200032; 2. 复旦大学附属肿瘤医院肿瘤研究所，复旦大学上海医学院肿瘤学系，上海 200032 　　［摘要］　Notch信号传导通路是影响细胞命运的重要通路之一，相邻细胞间通过Notch受体传递信号可以 调节多种细胞的分化、增殖和凋亡，影响器官形成和形态变化。Notch信号传导的变化与肿瘤的发生发展密切 相关，如脑肿瘤、乳腺癌、肝癌等。近年来研究表明，Notch异常通路介导卵巢癌的发生发展，尤其Notch3及 其信号传导分子参与肿瘤的化疗耐药与复发。文章对新近有关Notch3信号通路的重要分子调控卵巢癌的发生发 展进行综述。 　　 ［关键词］　Notch3；卵巢癌；信号传导通路 　　DOI: 10.3969/j.issn.1007-3969.2013.12.012 　　中图分类号：R737.31　　文献标识码：A　　文章编号：1007-3639(2013)12-1001-06 1 2 The mechanism of Notch3 mediated progression of ovarian cancer LIU Yang , YANG Gong , ZANG 1 Rong-yu (1.Departement of Gynecological Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; 2.Cancer Institute, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China) Correspondence to: ZANG Rong-yu E-mail: ryzang@ 　　［Abstract ］ Notch signal pathway is one of crucial pathways related to cell fate determination, regulating cell differentiation, proliferation and apoptosis, with an effect of organ formation and morphogenesis. Abnormal activation of Notch gene occurs in many tumor cells, such as brain tumors, breast cancer and hepatoma. Recent studies have been found that the notch pathway out of control was related with growth of ovarian cancer. And Notch3 involving in the development and progression of ova