芪蛭消疒徵胶囊治疗早期糖尿病肾病90例.DOCVIP

临床医学论文-芪蛭消疒徵胶囊治疗早期糖尿病肾病90例 ????????? 作者：彭月芹 孔祥芬 李秋英 贾海荣 胡宝峰 蔡欣红 黄明 朱红爱 任小强 【摘要】? 目的 观察中药芪蛭消疒徵胶囊治疗早期糖尿病肾病（DN）的临床疗效。方法 将早期DN患者90例随机分为2组，对照组予控制血糖、血压等常规治疗；治疗组47例在对照组治疗基础上，加用芪蛭消疒徵胶囊，每次4粒，每日3次。2组均连续治疗2个月为1个疗程，观察2组治疗前后尿蛋白排泄率（UAER）、24 h尿蛋白定量（Uprot）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）及血液流变学指标的变化及临床疗效。结果 治疗组UAER、24 h Uprot、TG、TC、HDL-C、LDL-C及血液流变学指标与对照组比较差异均有统计学意义（P＜0.01），且治疗组治疗后总有效率明显高于对照组，2组比较差异有统计学意义（P＜0.01）。结论 芪蛭消疒徵胶囊治疗早期DN疗效较好，在减少尿蛋白、改善肾功能、血脂及血液流变学状态方面具有重要作用。 【关键词】? 糖尿病病发症；糖尿病肾病；中药疗法　　　The therapeutic effect of Qizhixiaozheng capsule on 90 cases of early diabetic nephropathy　　【Abstract】? Objective? To observe the clinical effect of Qizhixiaozheng capsule on early diabetic nephropathy. Methods? 90 cases of early diabetic nephropathy were randomly divided into 2 groups. 43 patients in control group were detected and controlled the blood pressure and blood sugar. While 47 in treatment group were, on the basis of control group, treated by Qizhixiaozheng capsule, 4 pills each time, 3 times a day. The treatment course? was 2 months for both groups. To observe the changes of urine albumin excretion? rate （UAER）, 24 hours urine protein （UProt）, triglyceride （TG）, total cholesterol （TC）, high density lipoprotein cholesterin （HDL-C）, low density lipoprotein cholesterin （LDL-C） and the index of hemorheology as well as the clinical effect. Results? There was a significant difference between control? group and treatment group in all the figures and index （P0.05）, and the total effective rate in treatment group was superior to that in control group （P 0.01）. Conclusion? Qizhixiaozheng capsule has an obvious ther apeutic effect on early diabetic nephropathy and plays an important role in urine albumin reducing, enhancement of renal function, blood fat and hemorheology state.??? 　　【Key words】? Diabetic complication; Diabetic nephropathy; TC M therapy 　　糖尿病肾病（diabetic nephropathy,DN）是糖尿病（diabetes mellitus ,DM）严重的慢性并发症，由于近年来DM的发病率逐年上升，DN已成为最常见的继发性肾脏病，在大多数国家，DN已成为终末期肾病的