年产100吨桑黄多糖提取分离工艺的设计.docVIP

毕 业 设 计 题目：年产100吨桑黄多糖提取分离工艺的设计 学 生： 郑玉鹏 学 号： 201004040231 院 （系）： 生命科学与工程 专 业： 制药工程 指导教师： 秦俊哲 2014 年 5 月 22 日 年产100吨桑黄多糖提取分离工艺的设计 摘 要 桑黄多糖是国际公认的生物抗癌领域有效率最高的药用真菌提取物。对增强人体免疫功能及治疗疾病等方面都有明显作用。桑黄多糖的药理作用主要有抗癌抗肿瘤作用、增强免疫、抗突变、抗氧化、抗衰老等功能，从机理上来说，它们之间又有一定的相互联系。研究主要集中在抗癌抗肿瘤作用方面，但研究进展较为缓慢。由于目前国内天然桑黄数量非常稀少，而桑黄菌的人工栽培尚处于起步阶段难以形成稳定的医药工业产品来源。因此本设计采用液态深层培养技术进行桑黄菌的大规模培养来获得原料可以缓解这一现状。 提取工艺的好坏，直接关系到菌丝体的利用率和后续加工的难易。课题主要进行了桑黄的发酵以及提取分离的生产工艺设计。比较现有提取工艺，选取先进可行的工艺。本设计选用了超声提取等先进工艺，大大提升了提取效率。在工艺条件下进行物料衡算以及能量衡算，选择材质，尺寸和换热合适的反应器，然后进行平面布局的设计、人员配比、经济效益估算、劳动保护、“三废”处理。整个设计过程都是依据设计规范和标准进行的，设计结果满足工程设计要求、药品生产质量管理规范要求。 根据计算,做出药厂总平面布置图、工艺流程图、车间平面布置图、车间立面布置图和非标准设备的装配图五张图，设计说明书一份。 关键词：桑黄多糖,提取分离,发酵,工艺设计 The Design of the Polysaccharide Extraction and Separation Process That will Produce 100t Polysaccharide ABSTRACT Polysaccharide is internationally recognized as the most efficient biological anticancer field of medicinal fungi extract. It has obvious effects on strengthening humoral immune function and treating disease. Polysaccharide pharmacological effects are anti-tumor effects, enhance immunity, anti-mutagenic, anti-oxidation, anti-aging and others, from the mechanism, it has a certain linkages between them. Research focuses on the role of anti-tumor cancer, but the study progress was slowly. Because the number of domestic natural Phellinus is very scarce, and cultivated Phellinus is still in the initial stage，it is difficult to be the stable source of pharmaceutical products.This design adopts the submerged culture of Phellinus igniarius to obtain materials ，it can alleviate this situation. The quality of extraction process is directly related to the utilization of mycelium and subsequent processing of difficulty. The subject was mainly about the fermentation and extraction of Phellinus separation process design. Compared with the existing extraction technology, select advanced and feasible technology. This design uses th