统计遗传学与基因作图-关联分析.pptVIP

关联分析 Complex disease Disease determined by weak influence of many genes Within a family cluster, the combination of genes conferring risk may differ from one affected individual to another Environmental factors contribute Possibility of gene – environment interactions Potentially very complicated … but fortunately we sometimes find that one particular allele of a susceptibility gene is a demonstrable risk factor in a population 介绍 连锁分析是研究位点与疾病之间的关联，而关联分析研究的是等位与疾病之间的关联。 Linkage detectable over large genetic distances, typically 10-20 cM with large sample and many informative meioses Allelic ass