噬菌体治疗研究进展_王盛[1].pdfVIP

微生物学通报 JUL 20, 2009, 36(7): 1019~1024 Microbiology © 2009 by Institute of Microbiology, CAS tongbao@ 专论与综述 噬菌体治疗研究进展 王 盛 童贻刚* ( 100071) : , , 摘 要 噬菌体发现之初 便被前苏联和东欧医学界用来治疗细菌感染。但是 随着抗生素时代的 到来, 人们慢慢忽略了对噬菌体的深入研究。近来, 由于全球耐药菌感染率不断攀升, 用抗生素治 疗细菌感染面临了前所未有的挑战, 一些科学家和临床工作者开始重新把注意力集中到噬菌体研 究上来, 并在这个领域取得了极大的进展, 尤其是通过大量的实验证明: 噬菌体可以有效地提高 细菌感染的实验动物的存活率。本文就近几年国内外的科研工作者在噬菌体治疗领域所取得的进 展做一综述。 关键词: 噬菌体, 噬菌体治疗, 细菌感染 Recent Advance in Bacteriophage Therapy * WANG Sheng TONG Yi-Gang (State Key Laboratory of Pathogen and Biosecurity, Department of Pathogenic Molecular Biology Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China) Abstract: At the time of phage’s discovery, phage therapy was regarded as a possible treatment method against bacterial infection. Although phage therapy was used to treat and prevent bacterial infection in the former Soviet Union and Eastern Europe, it was abandoned by the West in the 1940s with the arrival of the antibiotic era. However, the ongoing evolution of bacterial multidrug-resistance has recently motivated the Western scientific community to reevaluate phage therapy for bacterial infections that are incurable by con- ventional chemotherapy. With the in-depth study of phages, it’s increasingly acknowledged tha