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Alimentary Pharmacology and Therapeutics
Review article: the functional abdominal pain syndrome
A. D. Sperber*, D. A. Drossman
*Department of Gastroenterology, SUMMARY
Tel-Aviv Medical Center, Tel-Aviv,
Israel.
Background
Faculty of Health Sciences,
Ben-Gurion University of the Negev, Functional abdominal pain syndrome (FAPS) is a debilitating disorder with
Beer-Sheva, Israel. constant or nearly constant abdominal pain, present for at least 6 months
UNC Center for Functional GI and and loss of daily functioning.
Motility Disorders, University of
North Carolina, Chapel Hill, NC, USA.
Aim
To review the epidemiology, pathophysiology and treatment of FAPS.
Correspondence to:
Dr A. D. Sperber, Department of Methods
Gastroenterology, Tel-Aviv Medical A literature review using the keywords: functional abdominal pain, chronic
Center, Faculty of Health Sciences,
Ben-Gurion University of the Negev, abdominal pain, irritable bowel syndrome and functional gastrointestinal
Beer-Sheva 84101, Israel. disorders.
E-mail: amy@bgu.ac.il
Results
Publication data No epidemiological studies have focused specifically on FAPS. Estimates of
Submitted 30 July 2010 prevalence range from 0.5% to 1.7% and tend to show a female predomi-
First decision 25 August 2010 nance. FAPS pathophysiology appears unique in that the pain is caused pri-
Resubmitted 7 December 2010 marily by amplified central perception of normal visceral input, rather than
Accepted 8 December 2010 by
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